Modelling of Drug Disposition Kinetics inIn VitroIntestinal Absorption Cell Models

Absorption and disposition kinetics of amoxicillin in normal human subjects.

Pharmacokinetic parameters of amoxicillin were studied in healthy fasted subjects afqer both oral and intravenous administration of a single 500-mg dose. Serum levels and urinary excretion rates were determined at various time intervals by a microbiological method. The conventional two-compartment model with elimination occurring from the central compartment was used to analyze the data. Mean v...

Oral absorption and disposition kinetics of lidocaine hydrochloride in dogs.

Oral Absorption and Disposition Kinetics of Lidocaine Hydrochloride in Dogs. R. N. BOYES, H. J. ADAMS AND B. R. DUCE 1 Maternal and Fetal Distribution of H3-Dihydromorphine in the Tolerant and Nontolerant Rat. S. Y. YEH AND L. A. WOODS 9 Retention of Inhaled Acetaldehyde in Man. JOHN L. EGLE, JR 14 Efflux of Chiorpromazine and Trifluoperazine from the Rat Brain. P. F. SPANO, N. H. NEFF, E. MACK...

A Tutorial on Target-Mediated Drug Disposition (TMDD) Models

Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 co...

Integro-differential models for percutaneous drug absorption

In this paper we propose a new mathematical models for percutaneous absorption of a drug based on integro-differential equations. We study the qualitative properties of the solution of the models and its numerical approximation. Simulation of proposed numerical methods is carried out.

Models to evaluate oral drug absorption